上海交通大学医学院附属仁济医院科研副院长，心内科主任医师、博导

个人简介：

      卜军教授，心内科主任医师、博导，上海交通大学医学院附属仁济医院科研副院长，国家级高层次人才、科技部中青年科技创新领军人才（2017年）、教育部新世纪优秀人才（2012年），国务院特殊津贴专家，科技部重点研发项目首席科学家。美国心脏协会专家会员(FAHA)、美国心脏病学会专家会员(FACC)、欧洲心脏病学会专家会员(FESC)，TCT、CRT、EuroPCR、EuroCHORUS和TCT-AP等国际心血管大会的国际主席团成员。擅长复杂危重冠脉疾病、先天性心脏病、心脏瓣膜病和左心耳封堵等结构性心脏病的微创介入及药物治疗，研究成果写入国际心血管内科学教科书和欧洲心血管病临床指南等行业规范，总引用3000余次。先后获 “吴孟超医学青年奖”、“树兰医学青年奖”、“上海市学术带头人”等。

近5年主持国家级重大重点科研项目：

1. 国家自然科学基金重点项目，编号82230014、“昼夜节律紊乱对腹主动脉瘤发生发展的影响：生物钟核受体REV-ERBα的关键作用”、2023/01/01-2027/12/31、263万元、在研、主持。

2. 国家自然科学基金重点项目，编号81930007、“昼夜节律对梗死后心肌修复和重构的影响：生物钟核受体RORα信号通路的关键作用”、2020/01/01-2024/12/31、297万元、在研、主持。

3. 国家重点研发专项，编号2018YFC1312800、“心脑血管疾病`协防共管’创新健康管理模式的开发与效果评价”、2018/09-2021/12、1534万元、在研、项目总负责人及首席科学家。

近5年来代表性论著（仅列IF>10）

1.      Sun LY#, Lyu YY#, Zhang HY, Shen Z, Lin GQ, Geng N, Wang YL, Huang L, Feng ZH, Guo X, Lin N, Ding S, Yuan AC, Zhang L, Qian K, Pu J*. Nuclear Receptor NR1D1 Regulates Abdominal Aortic Aneurysm Development by Targeting the Mitochondrial Tricarboxylic Acid Cycle Enzyme Aconitase-2. Circulation. 2022 Jul 26:101161CIRCULATIONAHA121057623. doi: 10.1161/CIRCULATIONAHA.121.057623. Epub ahead of print.

2.    Zhao Y#, Lu X#, Wan F, Gao L, Lin N, He J, Wei L, Dong J, Qin Z, Zhong F, Qiao Z, Wang W, Ge H, Ding S, Yang Y, Xiu J, Shan P, Yan F, Zhao S, Ji Y, Pu J *. Disruption of circadian rhythms by shift work exacerbates reperfusion injury in myocardial infarction. J Am Coll Cardiol. 2022. 79(21):2097-2115.

3.      Shi JF#, Tong RY#, Zhou M#, Gao Y, Zhao YC, Chen YF, Liu WH, Li GX, Lu D, Meng GF, Yuan AC, Hu LH, Pu J*. Circadian nuclear receptor Rev-erbα is expressed by platelets and regulates platelet activation and thrombus formation. Eur Heart J. 2022. 43(24):2317-2334.

4.      Zhao YC#, Gao LC#, Jiang CL, Chen JQ, Qin ZH, Zhong FY, Yang Y, Tong RY, Zhou M, Yuan AC, Pu J*. The transcription factor ZHX2 alleviates nonalcoholic steatohepatitis by transcriptional activation of PTEN. Hepatology. 2021. 1866(11): 165890.

5.      Jiang P#, Feng ZH#, Sheng L#, Hu CX, Ma X, Zhang SY, Wu, LM, Xiao X, Wang QX, Guo CJ, Qiu DK; Fang JY, Xu JR, Gershwin Merrill Eric, Jiang M*, Ma X*, Pu J*. Morphological, functional and tissue characterization of silent myocardial involvement in patients with primary biliary cholangitis. Clin Gastroenterol Hepatol. 2021.S1542-3565(21):00915.

6.      Gu ZC#, Wei AH#, Zhang C#, Wang XH, Zhang L, Shen L, Li Z, Pan MM, Liu XY, Pu J*, Lin HW*. Risk of major gastrointestinal bleeding with new vs conventional oral anticoagulants: a systematic review and meta-analysis. Clin Gastroenterol Hepatol. 2020.18(4):792-799.

7.      Leng S#, Ge H#, He J, Kong L, Yang Y, Yan F, Xiu J, Shan P, Zhao S, Tan RS, Zhao X, Koh AS, Allen JC, Hausenloy DJ, Mintz GS, Zhong L, Pu J*. Long-term prognostic value of cardiac MRI left atrial strain in ST-segment elevation myocardial infarction. Radiology.2020.296(2):299-309.

8.      Xu L#, Su Y#, Zhao Y#, Sheng X, Tong R, Ying X, Gao L, Ji Q, Gao Y, Yan Y, Yuan A, Wu F, Lan F, Pu J*. Melatonin differentially regulates pathological and physiological cardiac hypertrophy: Crucial role of circadian nuclear receptor RORα signaling. J Pineal Res.2019.67(2): e12579.

9.      Ding S#, Lin N#, Sheng X#, Zhao Y, Su Y, Xu L, Tong R, Yan Y, Fu Y, He J, Gao Y, Yuan A, Ye L, Reiter RJ, Pu J*. Melatonin stabilizes rupture-prone vulnerable plaques via regulating macrophage polarization in a nuclear circadian receptor RORα-dependent manner. J Pineal Res.2019.67(2): e12581.

10.   Zhao Y#, Wang F#, Gao L#, Xu L, Tong R, Lin N, Su Y, Yan Y, Gao Y, He J, Kong L, Yuan A, Zhuge Y, Pu J*. Ubiquitin-specific protease 4 is an endogenous negative regulator of metabolic dysfunctions in nonalcoholic fatty liver disease. Hepatology.2018.68(3):897-917.

11.   Guo Q#, Wu LM#, Wang Z, Shen JY, Su X, Wang CQ, Gong XR, Yan QR, He Q, Zhang W, Xu JR*, Jiang M*, Pu J*. Early detection of silent myocardial impairment in patients with new onset drug-naïve systemic lupus erythematosus -- a three-center prospective study. Arthritis & Rheumatology.2018.70(12):2014-2024.

12.   Pu J*, Ding S, Ge H, Han Y*, Lin R, Guo J, Lin R, Su X, Zhang H, Chen L, He B*. EARLY-MYO investigators (early routine catheterization after alteplase fibrinolysis versus primary PCI in acute ST-segment-elevation myocardial infarction). Circulation.2017.136(16):1462-1473.

13.   Zhao Y#, Xu L#, Ding S#, Lin N, Ji Q, Gao L, Su Y, He B*, Pu J*. Novel protective role of the circadian nuclear receptor retinoic acid-related orphan receptor-α in diabetic cardiomyopathy. J Pineal Res.2017.62(3):12378.

14.   Deng KQ#, Wang A#, Ji YX#, Zhang XJ, Fang J, Zhang Y, Zhang P, Jiang X, Gao L, Zhu XY, Zhao Y, Gao L, Yang Q, Zhu XH, Wei X, Pu J*, Li H*. Suppressor of IKKε is an essential negative regulator of pathological cardiac hypertrophy. Nat Commun.2016.7:11432.

15.   He B, Zhao Y, Xu L, Gao L, Su Y, Lin N, Pu J*. The nuclear melatonin receptor RORα is a novel endogenous defender against myocardial ischemia/reperfusion injury. J Pineal Res.2016.60(3):313-326.

16.   Ying X#, Zhao Y#, Yao T, Yuan A, Xu L, Gao L, Ding S, Ding H, Pu J*, He B*. Novel protective role for ubiquitin-specific protease 18 in pathological cardiac remodeling. Hypertension. 2016.68(5):1160-1170.

17.   He B, Zhao YC, Gao LC, Ying XY, Xu LW, Su YY, Ji QQ, Lin N, Pu J*. Ubiquitin-specific protease 4 is an endogenous negative regulator of pathological cardiac hypertrophy. Hypertension. 2016.67(6):1237-1248.

18.   Pu J, Mintz GS, Biro S, Lee JB, Stone GW, Weisz G, Maehara A*. Insights into echo-attenuated plaques, echolucent plaques, and plaques with spotty calcification: novel findings from comparisons among intravascular ultrasound, near-infrared spectroscopy, and pathological histology in 2,294 human coronary artery segments. J Am Coll Cardiol.2014.63(21):2220-2233.

19.   Pu J#, Yuan A#, Shan P, Gao E, Wang X, Wang Y, Lau W, Ma XL*, He B*. Cardiomyocyte expressed farnesoid-X-receptor is a novel apoptosis mediator and contributes to myocardial ischemia/reperfusion injury. Eur Heart J. 2013.34:1834-1845.

20.   Pu J, Mintz GS, Brilakis ES, Banerjee S, Abdel-Karim AR, Maini B, Biro S, Lee JB, Stone GW, Weisz G, Maehara A*. In vivo characterization of coronary plaques: novel findings from comparing greyscale and virtual histology intravascular ultrasound and near-infrared spectroscopy. Eur Heart J.2012.33:372-383.