Related research results from Department of Clinical Nutrition in our hospital published online (Impact factor of 12.48 points)

Recently, Department of Clinical Nutrition in our hospital came good news that postgraduate student Haixia Feng, guided by Director Yanping Wan online-published an article titled "In utero exposure to 25 (OH) D and risk of childhood asthma, wheeze and respiratory tract infections: a meta-analysis of birth Cohort studies" in the world famous journal "The Journal of Allergy and Clinical Immunology", which ranks 1st of 25 in the Allergy category and 5th of 150 in the Immunology category, with SCI impact factor of 12.48 points.

Asthma is a common chronic respiratory disease, which cause recurrent wheezing, shortness of breath, chest tightness or cough and other symptoms. There are about 300 million patients worldwide, and more than 15 million asthma patients in China. In 2013, according to survey results from China's pediatric asthma collaborative group, the total prevalence was up to 3.02% in children under the age of 14 in urban areas all over the country. Asthma is well known worldwide as a disease characterized by reversible airway obstruction, wheezing, airway hyperresponsiveness, and chronic inflammation that is usually initiated in childhood. A large number of studies have shown that the level of maternal vitamin D during pregnancy was related to childhood asthma in the offspring, but many studies are not entirely consistent. Studies also suggested that asthma and respiratory tract infection are closely related. Research group of Yanping Wan and Ka He strictly evaluated the quality of the articles, and summarized a blend of 16 prospective birth cohort studies. All these studies chose the level of vitamin D in maternal peripheral blood or cord blood as exposure factors, and observed childhood asthma, wheezing or respiratory tract infection as endpoint events. The team conducted a complex heterogeneity analysis, stratification analysis, sensitivity analysis, reasonable weight estimation, and selected random effects model. Their results showed that the level of maternal vitamin D during pregnancy was negatively correlated with the occurrence of childhood asthma or wheezing in the offspring. The results of this study are consistent with results from two recently published high-quality randomized controlled clinical trial of vitamin D supplementation during pregnancy, so that are more convincing. In addition, some data of the research results, after the additional calculations by the original authors, provides new valuable data for this study, and thus offers more reliable results.

As the corresponding author, Yanping Wan, Director of Department of Clinical Nutrition of our hospital, said that vitamin D is a kind of inexpensive nutrient which can be easily obtained and may have far-reaching significance in the early programming and follow-up inflammatory regulation during human life. Therefore, it has a deep clinical and social value to pay attention to the reasonable supplementation and regular monitoring of maternal vitamin D during pregnancy. (Translator: Weiwei Zhang)