High success rate Helicobacter pylori eradication optimized treatment

The failure rate of first-line treatment for Helicobacter pylori (Hp) infection is increasing year by year, mainly due to increased antibiotic resistance. In order to improve the eradication rate, individualized and precise treatment strategies are needed. The following are currently clinically proven and effective optimization solutions:  Precision treatment based on antimicrobial susceptibility testing。A combination of antibiotics with high efficacy。Special Populations Program。Management after treatment failure

Refractory peptic ulcer
Refractory peptic ulcer is usually defined as an ulcer that does not heal after 8 weeks of standard acid suppression, and its common causes include persistent Helicobacter pylori (Hp) infection, long-term use of NSAIDs, abnormal gastric acid secretion, and specific causes (eg, gastrinoma). Our treatment begins with identifying and removing the cause. Endoscopic follow-up is essential, and gastroscopy should be repeated after treatment to assess healing, biopsy should be performed。 High-risk patients with bleeding risk are recommended for regular endoscopic reexamination. The standardized management of refractory ulcers requires multidisciplinary collaboration, combined with etiological treatment, intensive acid suppression, and close follow-up to promote ulcer healing and prevent complications.

MALT lymphoma

Helicobacter pylori (Hp) eradication therapy (14 days of bismuth quadruple therapy) is the first choice for gastric MALT lymphoma, and most patients achieve complete remission. After successful HP eradication, a small number of patients require further hematological treatment. Follow-up plan: Regular endoscopy and biopsy after treatment to evaluate the efficacy. Long-term follow-up requires monitoring for recurrence risk.