The Department of Biliary-Pancreatic Surgery of Renji Hospital Affiliated to Shanghai Jiaotong  University School of Medicine was founded in October 2013. It was formerly known as the Biliary Tract Professional Group of Department of General Surgery in Renji Hospital. Famous national surgical experts, including Prof. Lan Xichun, Prof. Kuang Yaolin, Prof. Shi Weijin, Prof. Wang Pingzhi, Prof. Zhang Baigen, Prof. Chen Zhiping, Prof. Wu Zhiyong, Prof. Cao Hui and so on, have made outstanding contributions in this field, which lays a good foundation for the establishment of Dept. of Biliary-Pancreatic Surgery of  Renji Hospital. Currently, biliary-pancreatic surgery is a national key clinical specialty, a member unit of Shanghai Biliary Diseases Consultation Center, the Biliary Diseases Diagnosis and Treatment Center of Shanghai Jiaotong University School of Medicine, the Pancreatic Disease Diagnosis and Treatment Center of Shanghai Jiaotong University School of Medicine, as well as a key and characteristic discipline of Renji Hospital. It is also the location of the Institute of Biliary Diseases (Renji Branch), Shanghai Jiaotong University School of Medicine, and Shanghai Key Laboratory for Cancer Systems Regulation and Clinical Translation (under preparation).

The Department of Biliary-Pancreatic Surgery of Renji Hospital has a comprehensive surgical team that is proficient in modern surgical techniques such as laparotomy, minimally invasive laparoscopic surgery, robotic surgery, and endoscopic surgery. It benchmarks against the domestic first-class level and has gradually gained influence in the discipline of biliary and pancreatic surgery. Since its establishment, the annual outpatient volume, number of discharges, number of surgeries, number of key diseases and key surgeries have increased year by year. It has maturely carried out large-scale and complex surgeries for various biliary and pancreatic diseases, especially in the standardized treatment for pancreatic tumors and biliary tract tumors. More than 600 cases of biliary and pancreatic tumors are cured in Renji Hospital every year.

The Department of Biliary and Pancreatic Surgery of Renji Hospital has been the first in China to advocate the concept of "total mesopancreatic resection for pancreatic head cancer", providing more patients with the opportunity for radical surgery and improving the rates of R0 resection and five-year survival. The department has also proposed a series of treatment strategies for pancreatic cancer patients with liver metastasis, improved their overall survival. The department was among the early proponents of the treatment concept of anatomic hepatectomy combined with hilar lymph node dissection for intrahepatic cholangiocarcinoma, which has yielded satisfactory therapeutic outcomes. The department has pioneered and perfected various surgical approaches for radical resection of gallbladder cancer both domestically and internationally, filling several gaps in treatment concepts on a global scale. In addition, the Department of Biliary and Pancreatic Surgery of Renji Hospital has also conducted research on personalized treatment for gallbladder cancer patients with mutations in ErbB signaling pathway. Through the established gallbladder cancer biobank, it has effectively prolonged the survival time of gallbladder cancer patients without increasing adverse reactions, setting an example of translating basic research into clinical practice.

The Department of Biliary and Pancreatic Surgery possesses first-rate endoscopic and laparoscopic technology in China, utilizing laparoscopy, cholangioscopy, and duodenoscopy for minimally invasive treatment of extrahepatic bile duct stones; percutaneous transhepatic biliary puncture (PTC); retrograde cholangiopancreatography (ERCP); percutaneous transhepatic gallbladder drainage (PTGBD); transsinusoidal biliary intervention; single-port laparoscopic cholecystectomy. In addition, the department performs laparoscopic/robotic pancreaticoduodenectomy, distal pancreatectomy, splenectomy, partial hepatectomy and various types of abdominal wall hernia repair (such as inguinal hernia, incisional hernia, Parastomal hernia), with minimally invasive surgeries accounting for over 60% of the total surgical volume in the Biliary-Pancreatic Surgery Department.

The Department of Biliary-Pancreatic Surgery of Renji Hospital integrates the concept of rapid recovery with day surgery, adhering to the principles of being fast, precise, and minimally invasive. Annually, it performs 4,000 day surgeries, with laparoscopic cholecystectomy, hernia repair, and ERCP comprising over 80% of these surgeries. This approach significantly reduces both the duration of hospital stays and associated costs.

The Department of Biliary-Pancreatic Surgery has established a series of research directions focused on biliary and pancreatic tumors. It has achieved global firsts in successfully creating animal and cell models of gallbladder cancer and in constructing the mutation spectrum for this disease. Additionally, it pioneered targeted therapy for gallbladder cancer internationally. At the same time, a clinical specimen library and database were established, and the application of three-dimensional visualization during the perioperative period of biliary tumors, the clinical application of total mesopancreatic resection, conversion therapy of advanced pancreatic cancer, and strategies for hilar lymph node dissection in intrahepatic cholangiocarcinoma were carried out. Various clinical studies include research on the scope of radical resection of gallbladder cancer and research on the metabolic causes of gallstones. Since its inception, the department has undertaken over 60 research projects, with 31 at the national level and 13 at the provincial or ministerial level, and has published over 100 papers in SCI-indexed journals.

Currently, the East Campus of the Department of Biliary-Pancreatic Surgery has 47 beds, focusing on biliopancreatic and abdominal wall hernia diseases, including various biliary tract diseases (stones in gallbladder, intrahepatic and extrahepatic bile duct, choledochal cysts, gallbladder cancer, bile duct and ampullary cancer and so on.), pancreatic diseases (pancreatic cysts, pancreatic endocrine tumors, pancreatic cancer and so on.) ,and various types of inguinal hernia, incisional hernia and so on . The West Campus has 24 beds, mainly focusing on retroperitoneal tumors and abdominal wall surgical diseases, including liposarcoma, leiomyosarcoma, malignant mesothelium tumors and various types of inguinal hernia, incisional hernia, hiatal hernia, and so on. The South Campus has 51 beds and treats various general surgical diseases, including benign and malignant diseases of the liver, gallbladder and pancreas, tumors of the stomach, small intestine and colorectum, benign and malignant tumors of the thyroid and breast , various types of abdominal wall hernia and poor wound healing,and  so on. The Department of Biliary-Pancreatic Surgery currently has 45 clinical physicians on staff, including 26 with senior professional titles, 2 doctoral supervisors, and 9 master's supervisors.